Paul's [131 Second Ave. (bet. 7th St. and St. Mark's Pl.) 212-529-3033]
This burger is about as greasy as they come, but it's also very good. It's big and juicy and I recommend that you get it on an English muffin. I know that sounds weird, but trust me on this one. If you want fries, try the sweet potato variety. However, just a burger should be enough to fill you up.